Perforin-2 (P2) is a pore-forming protein with cytotoxic activity against intracellular bacterial pathogens.P2 knockout (P2KO) mice are unable to control infections and die from normally non-lethal bacterial infections.Here we show that P2KO mice as compared to WT mice show significantly higher levels of systemic inflammation, measured by inflammat
Álvaro Machado,1 Tiago Torres1,2 1Department of Dermatology, Centro Hospitalar Universitário do Porto, Porto, Portugal; 2Instituto de Ciências Biomédicas Abel Salazar, University of Porto, Porto, Portugal Abstract: Psoriasis is a common chronic immune-mediated skin disease, with systemic involvement and significant impact
Abstrak Permasalahan yang sering terjadi pada lingkungan masyarakat adalah kesulitan untuk mendeteksi mengenai akan datangnya banjir secara dini, sehingga berdampak pada kerugian materil dan korban jiwa.Untuk itu diperlukan suatu sistem yang dapat mendeteksi banjir secara dini agar masyarakat dapat langsung mengetahui informasi peringatan yang cepa
Abstract The efficiency of geopolymers as an effective immobilization system for various hazardous waste materials can be enhanced by adding PbO to improve its radiation shielding characteristics.In this study, the impact of PbO addition on the shielding properties of geopolymer composites was examined to evaluate the gamma radiation shielding char
Neutrophils play a central role in eliminating bacterial pathogens, but may also contribute to end-organ damage in sepsis.Interleukin-8 (IL-8), a key modulator of neutrophil function, signals through neutrophil specific surface receptors CXCR-1 and CXCR-2.In this study a mechanistic computational model was used to evaluate and deploy an extracorpor